(R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Base Information

• Chemical Name: (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS No.: 86688-19-9
• Molecular Formula: C₁₇H₂₀N₄O₄S
• Molecular Weight: 376.436
• Mol file: 86688-19-9.mol

Synonyms:

Chemical Property of (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 2 articles about (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7β-Aminodeacetoxycephalosporanic acid (22252-43-3,26395-99-3,70287-30-8,72059-35-9) → (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (57802-21-8,86688-18-8,86688-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile; CH₂Cl₂ / 1 h / Heating

2: propylene oxide / acetonitrile / 2 h / Ambient temperature

With methyloxirane; In dichloromethane; acetonitrile;

DOI:10.1021/jm00365a019

Reference yield:

C11H18N2O3SSi (41360-37-6) + (N-Methyl-hydrazino)-phenyl-acetyl chloride; hydrochloride (54186-58-2) → (R)-3-Methyl-7-[2-(N-methyl-hydrazino)-2-phenyl-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (57802-21-8,86688-18-8,86688-19-9)

Guidance literature:

With methyloxirane; In acetonitrile; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm00365a019

upstream raw materials:

C₁₁H₁₈N₂O₃SSi

(N-Methyl-hydrazino)-phenyl-acetyl chloride; hydrochloride

7β-Aminodeacetoxycephalosporanic acid