(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

Base Information

Chemical Name:(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione
CAS No.:1579952-93-4
Molecular Formula:C₂₈H₂₉FN₂O₄
Molecular Weight:476.548
Hs Code.:

(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

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Chemical Property of (1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

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Technology Process of (1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

There total 5 articles about (1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1579952-92-3
C₂₈H₃₁FN₂O₄

: 1579952-93-4
(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

Guidance literature:: With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide; In dichloromethane; Inert atmosphere; Reflux;
DOI:10.1021/ml500008w

Reference yield:

: 618386-45-1
(3R,3aS,4S,4aR,7R,8aS,9aR)-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-7-(hydroxymethyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one

: 1579952-93-4
(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / Inert atmosphere

2: [bis(acetoxy)iodo]benzene; dirhodium tetraacetate; magnesium oxide / dichloromethane / Inert atmosphere; Reflux

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide; potassium carbonate; In dichloromethane;
DOI:10.1021/ml500008w

Reference yield:

: 618386-13-3
C₂₆H₂₆FNO₃

: 1579952-93-4
(1R,3aR,4aR,4'S,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyloctahydro-1H-spiro[naphtho[2,3-c]furan-6,4'-oxazolidine]-2',3(7H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / water; 1,4-dioxane / 1 h / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.08 h / 0 °C / Inert atmosphere

4.1: potassium carbonate / Inert atmosphere

5.1: [bis(acetoxy)iodo]benzene; dirhodium tetraacetate; magnesium oxide / dichloromethane / Inert atmosphere; Reflux

With hydrogenchloride; dirhodium tetraacetate; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; potassium tert-butylate; magnesium oxide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/ml500008w