(2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide

Base Information

Chemical Name:(2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide
CAS No.:104261-81-6
Molecular Formula:C15H14N2O
Molecular Weight:238.289
Hs Code.:
DSSTox Substance ID:DTXSID101234453
Mol file:104261-81-6.mol

Synonyms:104261-81-6;(2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide;DTXSID101234453

Suppliers and Price of (2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:238.110613074
Heavy Atom Count:18
Complexity:299

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NC2=CC=CC=C21)C(=O)NC3=CC=CC=C3
Isomeric SMILES:C1[C@H](NC2=CC=CC=C21)C(=O)NC3=CC=CC=C3

Technology Process of (2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide

There total 5 articles about (2S)-2,3-Dihydro-N-phenyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 329015-59-0
N-phenyl-(S)-N^α-(tert-butoxycarbonyl)indoline-2-carboxamide

: 104261-81-6
anilide of (S)-indoline-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/S0957-4166(00)00414-6

Reference yield:

: 79815-20-6,78348-24-0
(S)-indoline-2-carboxylic acid

: 104261-81-6
anilide of (S)-indoline-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / 0.5 M aq. NaOH / dioxane / 16 h / 20 °C

2: N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3: tetrahydrofuran / 14 h / 20 °C

4: 94 percent / TFA / CH₂Cl₂ / 4 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0957-4166(00)00414-6

Reference yield:

: 144069-67-0,133851-52-2
(S)-N-tert-butoxycarbonylindoline-2-carboxylic acid

: 104261-81-6
anilide of (S)-indoline-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

2: tetrahydrofuran / 14 h / 20 °C

3: 94 percent / TFA / CH₂Cl₂ / 4 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(00)00414-6