(+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Base Information

Chemical Name:(+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt
CAS No.:111001-52-6
Molecular Formula:C₆H₁₂FNO₂*ClH
Molecular Weight:185.626
Hs Code.:

Synonyms:

Suppliers and Price of (+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

There total 2 articles about (+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110903-12-3
(1RS,8RS,10RS,11SR)-10-dinitroanilino-11-fluoro-3,3,5,5-tetraisopropyl-2,4,6-trioxa-3,5-disilabicyclo<6.3.0>undecane

: 111001-52-6
(+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: 21 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

2: 1.) Dowex 2(OH^-) resin, 2.) HCl (1N) / 1.) acetone, water, RT, 24 h

With hydrogenchloride; Dowex 2(OH^-) resin; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jm00163a030

Reference yield:

: 123238-58-4
(+/-)-(1α,2β,3β,4α)-4-<2,4-dinitriphenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 111001-52-6
(+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Guidance literature:: With hydrogenchloride; Dowex 2(OH^-) resin; Yield given. Multistep reaction; 1.) acetone, water, RT, 24 h;
DOI:10.1021/jm00163a030

Reference yield:

: 111001-52-6
(+/-)-(1α,2β,3β,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

: 131101-20-7
(+/-)-(1α,2β,3β,4α)-4-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-3-fluoro-2-hydroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 67.7 percent / Et₃N / ethanol / 24 h / Heating

2: 71 percent / NaOAc, AcOH / H₂O / Ambient temperature

With sodium acetate; acetic acid; triethylamine; In ethanol; water;
DOI:10.1021/jm00107a006