Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine
• CAS No.: 106502-57-2
• Molecular Formula: C₆H₁₅N*C₄₇H₄₄N₅O₉PS
• Molecular Weight: 987.126

Synonyms:

Chemical Property of Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Useful:

Technology Process of Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine

There total 4 articles about Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Dithiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (106502-51-6) + triethylamine (121-44-8) → Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine (106502-57-2)

Guidance literature:

With pyridine; hypophosphorous acid; for 0.166667h;

DOI:10.1021/jo00381a047

Reference yield:

N4-benzoyl-2'-deoxycytidine (4836-13-9) → Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine (106502-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / dimethylformamide / 0.17 h

2: mesitylenedisulfonyl chloride (MDS) / 0.17 h

3: 100 percent / phosphinic acid (PSA), pyridine / 0.17 h

With pyridine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; hypophosphorous acid; In N,N-dimethyl-formamide;

DOI:10.1021/jo00381a047

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → Thiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine (106502-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: mesitylenedisulfonyl chloride (MDS) / 0.17 h

2: 100 percent / phosphinic acid (PSA), pyridine / 0.17 h

With pyridine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; hypophosphorous acid;

DOI:10.1021/jo00381a047

upstream raw materials:

Dithiophosphoric acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

triethylamine

cyclohexylammonium S,S-diphenyl phosphorodithioate

N-(1-{(2R,4S,5R)-4-Hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

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