3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

Base Information

Chemical Name:3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione
CAS No.:21371-40-4
Molecular Formula:C₃₃H₃₁N₇O₄S
Molecular Weight:621.72
Hs Code.:

3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2<i>r</i><i>N</i>,3a<i>c</i>,6a<i>c</i>)-tetrahydro-spiro[furo[2,3-<i>d</i>]thiazole-2,4'-imidazolidine]-2',5'-dione

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Chemical Property of 3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

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Technology Process of 3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

There total 11 articles about 3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59-43-8
vitamin B₁

: 21371-40-4,21477-25-8,24445-90-7,24513-94-8
3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 1.5 h

2: HCl / ethanol

3: Et₃N / dimethylformamide

4: acetone; acetic acid / 8 h / Heating

5: acetone; acetic acid / 13 h / Heating

With hydrogenchloride; triethylamine; In ethanol; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 5-(2-hydroxy-ethyl)-4-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-thiazolium; chloride

: 21371-40-4,21477-25-8,24445-90-7,24513-94-8
3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / dimethylformamide

2: acetone; acetic acid / 8 h / Heating

3: acetone; acetic acid / 13 h / Heating

With triethylamine; In acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 103-71-9
phenyl isocyanate

: 21371-40-4,21477-25-8,24445-90-7,24513-94-8
3a-methyl-3-[2-methyl-4-(3-phenyl-ureido)-pyrimidin-5-ylmethyl]-1',3'-diphenyl-(2rN,3ac,6ac)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dione

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 1.5 h

2: HCl / ethanol

3: Et₃N / dimethylformamide

4: acetone; acetic acid / 8 h / Heating

5: acetone; acetic acid / 13 h / Heating

With hydrogenchloride; triethylamine; In ethanol; acetic acid; N,N-dimethyl-formamide; acetone;