Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

Base Information

Chemical Name:Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic
CAS No.:99528-76-4
Molecular Formula:C₄₃H₅₈N₈O₁₀
Molecular Weight:846.981
Hs Code.:

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Chemical Property of Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

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Technology Process of Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

There total 15 articles about Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 99461-44-6
t-butoxycarbonyl-L-2-amino-4-(3-pyridyl)butyric acid

: (S)-2-{(R)-2-[(S)-2-((S)-2-Amino-propionylamino)-propionylamino]-propionylamino}-6-benzyloxycarbonylamino-hexanoic acid pyridin-4-ylmethyl ester

: 99528-76-4
Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

Reference yield:

: 1802-16-0
3-(3-pyridinyl)propionaldehyde

: 99528-76-4
Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

Guidance literature:: Multi-step reaction with 8 steps

1: 17 g / ammonium chloride / diethyl ether; H₂O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h

2: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature

3: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature

4: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h

5: 94 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8

6: 6M aq. hydrochloric acid / 3 h / Heating

7: 71 percent / ethyl diisopropylamine / dimethylformamide

8: 91 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole

With hydrogenchloride; thionyl chloride; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N,N,N',N'-tetramethylguanidine; In methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 99461-40-2
2-Amino-4-pyridin-3-yl-butyronitrile

: 99528-76-4
Boc-Ala(3 Pm)-Ala-Ala-D-Ala-Lys(Z)-OPic

Guidance literature:: Multi-step reaction with 7 steps

1: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature

2: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature

3: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h

4: 94 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8

5: 6M aq. hydrochloric acid / 3 h / Heating

6: 71 percent / ethyl diisopropylamine / dimethylformamide

7: 91 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole

With hydrogenchloride; thionyl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N,N,N',N'-tetramethylguanidine; In methanol; N,N-dimethyl-formamide;