2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester
• CAS No.: 102990-86-3
• Molecular Formula: C₃₈H₄₀NO₁₁P
• Molecular Weight: 717.709

Synonyms:

Chemical Property of 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester

There total 5 articles about 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S*,4R*)-4-allyl-1-tert-butyldimethylsilyl-3-(4-methyl-2-oxo-1,3-dioxolan-4-yl)-2-azetidinone (84829-80-1,84848-59-9,91177-16-1) → 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ5-phosphanylidene)-acetoxymethyl ester (102990-86-3)

Guidance literature:

Multi-step reaction with 5 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

2: 1.) BF₃-etherate / 1.) CH₂Cl₂, room temperature; 2.) CrO₃, pyridine, CH₂Cl₂, 30 min, ice-cooling

3: 80 percent / tetraethylammonium fluoride dihydrate, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

4: 1.) triethylamine, molecular sieves 4A / 1.) THF, room temperature; 2.) DMF, 10 min, ice-cooling, 5 min, room temperature

5: 1.) thionyl chloride, 2,6-lutidine; 2.) 2,6-lutidine / 1.) THF, -20 degC, 30 min, ice-cooling, 30 min; 2.) dioxane, room temperature

With 2,6-dimethylpyridine; thionyl chloride; 4 A molecular sieve; tetraethylammonium fluoride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.33.4361

Reference yield:

(3S*,4R*)-1-tert-butyldimethylsilyl-4-(2,3-epoxypropyl)-3-<(4R*)-4-methyl-2-oxo-1,3-dioxolan-4-yl>-2-azetidinone (102990-80-7,103065-36-7,103065-43-6,103065-44-7) → 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ5-phosphanylidene)-acetoxymethyl ester (102990-86-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) BF₃-etherate / 1.) CH₂Cl₂, room temperature; 2.) CrO₃, pyridine, CH₂Cl₂, 30 min, ice-cooling

2: 80 percent / tetraethylammonium fluoride dihydrate, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

3: 1.) triethylamine, molecular sieves 4A / 1.) THF, room temperature; 2.) DMF, 10 min, ice-cooling, 5 min, room temperature

4: 1.) thionyl chloride, 2,6-lutidine; 2.) 2,6-lutidine / 1.) THF, -20 degC, 30 min, ice-cooling, 30 min; 2.) dioxane, room temperature

With 2,6-dimethylpyridine; thionyl chloride; 4 A molecular sieve; tetraethylammonium fluoride; acetic acid; triethylamine; boron trifluoride diethyl etherate; In tetrahydrofuran;

DOI:10.1248/cpb.33.4361

Reference yield:

Acetic acid 3-[(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-2-yl]-2-oxo-propyl ester (91096-72-9,103065-38-9) → 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ5-phosphanylidene)-acetoxymethyl ester (102990-86-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / tetraethylammonium fluoride dihydrate, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

2: 1.) triethylamine, molecular sieves 4A / 1.) THF, room temperature; 2.) DMF, 10 min, ice-cooling, 5 min, room temperature

3: 1.) thionyl chloride, 2,6-lutidine; 2.) 2,6-lutidine / 1.) THF, -20 degC, 30 min, ice-cooling, 30 min; 2.) dioxane, room temperature

With 2,6-dimethylpyridine; thionyl chloride; 4 A molecular sieve; tetraethylammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran;

DOI:10.1248/cpb.33.4361

upstream raw materials:

triphenylphosphine

(3S^*,4R^*)-4-allyl-1-tert-butyldimethylsilyl-3-(4-methyl-2-oxo-1,3-dioxolan-4-yl)-2-azetidinone

(3S^*,4R^*)-4-(3-acetoxy-2-oxopropyl)-3-<(4R^*)-4-methyl-2-oxo-1,3-dioxolan-4-yl>-2-azetidinone

Acetic acid 3-[(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-2-yl]-2-oxo-propyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 102990-86-3 2,2-Dimethyl-propionic acid 2-[(2R,3S)-2-(3-acetoxy-2-oxo-propyl)-3-((R)-4-methyl-2-oxo-[1,3]dioxolan-4-yl)-4-oxo-azetidin-1-yl]-2-(triphenyl-λ⁵-phosphanylidene)-acetoxymethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send