Technology Process of 6,6'-bis(diphenylphosphanyl)-N2,N2,N2',N2',4,4'-hexamethyl-1,1'-biphenyl-2,2'-diamine
There total 6 articles about 6,6'-bis(diphenylphosphanyl)-N2,N2,N2',N2',4,4'-hexamethyl-1,1'-biphenyl-2,2'-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2'-dibromo-6,6'-bis(dimethylamino)-4,4'-dimethyl-1,1'-biphenyl;
With
n-butyllithium;
In
diethyl ether;
at 0 ℃;
for 3h;
Inert atmosphere;
Schlenk technique;
chloro-diphenylphosphine;
In
diethyl ether;
at -40 ℃;
for 72h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/ejic.201300473
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Schlenk technique
2.1: zinc / methanol / Inert atmosphere; Schlenk technique; Reflux
2.2: Inert atmosphere; Schlenk technique
3.1: sodium hydride / tetrahydrofuran / 35 h / Inert atmosphere; Schlenk technique; Reflux
4.1: n-butyllithium / diethyl ether / 3 h / 0 °C / Inert atmosphere; Schlenk technique
4.2: 72 h / -40 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; copper; sodium hydride; zinc;
In
tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejic.201300473
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; sodium nitrite / water / 1.25 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
1.2: 1 h / 70 °C / Inert atmosphere; Schlenk technique
2.1: copper / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Schlenk technique
3.1: zinc / methanol / Inert atmosphere; Schlenk technique; Reflux
3.2: Inert atmosphere; Schlenk technique
4.1: sodium hydride / tetrahydrofuran / 35 h / Inert atmosphere; Schlenk technique; Reflux
5.1: n-butyllithium / diethyl ether / 3 h / 0 °C / Inert atmosphere; Schlenk technique
5.2: 72 h / -40 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; sulfuric acid; copper; sodium hydride; zinc; sodium nitrite;
In
tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1002/ejic.201300473
