(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Base Information

Chemical Name:(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate
CAS No.:187816-85-9
Molecular Formula:C₅₀H₅₃N₇O₇
Molecular Weight:864.014
Hs Code.:

(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Synonyms:

Suppliers and Price of (+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

There total 5 articles about (+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3-isocyanatophenyl)acetic acid ethyl ester

: 187816-85-9
(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

2: aq. NaOH / ethanol

3: HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.116

Reference yield:

: 187816-82-6
{3-[3-(4-hydroxymethylpiperidin-1-ylmethyl)phenoxy]propylcarbamoyl}methyl benzoate

: 187816-85-9
(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P, DEAD, HN₃ / tetrahydrofuran; benzene / 1 h / Ambient temperature

2: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 16 h, 2.) THF, reflux, 30 min

3: HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With tris-(2-chloro-ethyl)-amine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.45.116

Reference yield:

: 1027404-45-0
{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-phenyl}-acetic acid ethyl ester

: 187816-85-9
(+)-(R)-[3-(3-{4-[(2-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]phenyl}acetylamino)methyl]piperidin-1-ylmethyl}phenoxy)propylcarbamoyl]methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.116