Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate

Base Information

Chemical Name:Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate
CAS No.:220212-13-5
Molecular Formula:C₁₆H₁₉NO₆
Molecular Weight:321.33
Hs Code.:
DSSTox Substance ID:DTXSID601202873

Synonyms:Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate;DTXSID601202873;220212-13-5

Suppliers and Price of Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate

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Chemical Property of Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:321.12123733
Heavy Atom Count:23
Complexity:446

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC1CCN(C1OC(=O)C)C(=O)OCC2=CC=CC=C2

Technology Process of Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate

There total 5 articles about Phenylmethyl 2,3-bis(acetyloxy)-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69261-54-7,125982-42-5
1-(benzyloxycarbonyl)pyrrolidin-2-ol

: 220212-13-5
benzyl 2,3-diacetoxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Heating

2: 91 percent / N-methyl morpholine-N-oxide, H₂O, OsO₄ / 2-methyl-propan-2-ol; acetone

3: DMAP, pyridine / CH₂Cl₂

With pyridine; dmap; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In dichloromethane; acetone; toluene; tert-butyl alcohol;
DOI:10.1055/s-1998-1965

Reference yield:

: 68471-57-8
2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester

: 220212-13-5
benzyl 2,3-diacetoxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / N-methyl morpholine-N-oxide, H₂O, OsO₄ / 2-methyl-propan-2-ol; acetone

2: DMAP, pyridine / CH₂Cl₂

With pyridine; dmap; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1055/s-1998-1965

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 220212-13-5
benzyl 2,3-diacetoxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Na₂CO₃, H₂O / CH₂Cl₂

2: pyridinium tosylate, H₂O / acetone

3: toluene / Heating

4: 91 percent / N-methyl morpholine-N-oxide, H₂O, OsO₄ / 2-methyl-propan-2-ol; acetone

5: DMAP, pyridine / CH₂Cl₂

With pyridine; dmap; osmium(VIII) oxide; water; pyridinium p-toluenesulfonate; sodium carbonate; 4-methylmorpholine N-oxide; In dichloromethane; acetone; toluene; tert-butyl alcohol;
DOI:10.1055/s-1998-1965