N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide

Base Information

• Chemical Name: N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide
• CAS No.: 98189-03-8
• Molecular Formula: C₅₃H₉₃N₅O₄
• Molecular Weight: 864.353

Synonyms:

Chemical Property of N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide

There total 5 articles about N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-L-histidine (16832-24-9,103772-40-3,31534-22-2) → N,N-dihexadecyl-Nαhis-αala-(t-butoxycarbonyl)-L-alanyl>-Nim-benzyl-L-histidinamide (98189-03-8)

Guidance literature:

Multi-step reaction with 4 steps

2: 54 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; / CH₂Cl₂ / 1) 3 h; 0 deg C; 2) 15 h; room temp.

3: trifluoroacetic acid / CH₂Cl₂ / 2 h / Ambient temperature

4: triethylamine; 1-hydroxybenztriazole; dicyclohexylcarbodiimide; / CH₂Cl₂ / 1) 3 h; 0 deg C; 2) 15 h; room temp.

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1246/bcsj.58.172

Reference yield:

S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine (41840-28-2) → N,N-dihexadecyl-Nαhis-αala-(t-butoxycarbonyl)-L-alanyl>-Nim-benzyl-L-histidinamide (98189-03-8)

Guidance literature:

Multi-step reaction with 2 steps

2: triethylamine; 1-hydroxybenztriazole; dicyclohexylcarbodiimide; / CH₂Cl₂ / 1) 3 h; 0 deg C; 2) 15 h; room temp.

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1246/bcsj.58.172

Reference yield:

N,N-dihexadecyl-Nα-(t-butoxycarbonyl)-Nim-benzyl-L-histidinamide (98189-02-7) → N,N-dihexadecyl-Nαhis-αala-(t-butoxycarbonyl)-L-alanyl>-Nim-benzyl-L-histidinamide (98189-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: triethylamine; 1-hydroxybenztriazole; dicyclohexylcarbodiimide; / CH₂Cl₂ / 1) 3 h; 0 deg C; 2) 15 h; room temp.

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1246/bcsj.58.172

upstream raw materials:

L-N-Boc-Ala

(S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)-N,N-dihexadecyl-propionamide

1-benzyl-L-histidine

S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine

Downstream raw materials:

(S)-2-Amino-N-[(S)-2-(1-benzyl-1H-imidazol-4-yl)-1-dihexadecylcarbamoyl-ethyl]-propionamide

N,N-dihexadecyl-N^α_his-Α_ala-(6-bromohexanoyl)-L-alanyl>-N^im-benzyl-L-histidinamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 98189-03-8 N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send