N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

Base Information

Chemical Name:N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide
CAS No.:231957-30-5
Molecular Formula:C₄₁H₄₀N₆O₁₁
Molecular Weight:792.802
Hs Code.:

<i>N</i>-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl}-acetamide

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Chemical Property of N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

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Technology Process of N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

There total 1 articles about N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149622-93-5
<(2-Nitrobenzyl)oxy>methyl chloride

: 231957-27-0
N²-acetyl-5'-O-(4,4'-dimethoxytrityl)guanosine

: 231957-30-5
N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

Guidance literature:: With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; Yield given; Multistep reaction; 1.) (ClCH₂)2, 25 deg C, 60 min, 2.) 70 deg C, 30 min;
DOI:10.1055/s-1999-3098

Reference yield:

: 231957-30-5
N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

: 231957-32-7
2-Amino-9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

Guidance literature:: With methylamine; In ethanol; at 25 ℃; for 0.5h; Yield given;
DOI:10.1055/s-1999-3098

Reference yield:

: 231957-30-5
N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-acetamide

: Acetic acid (2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MeNH₂ / ethanol / 0.5 h / 25 °C

2: DMAP, pyridine / 0.25 h / 4 °C

With pyridine; dmap; methylamine; In ethanol;
DOI:10.1055/s-1999-3098