Benzoic acid, 2-[(tetrahydro-2-furanyl)thio]-, tetrahydro-2-furanyl ester

Base Information

• Chemical Name: Benzoic acid, 2-[(tetrahydro-2-furanyl)thio]-, tetrahydro-2-furanyl ester
• CAS No.: 104324-44-9
• Molecular Formula: C15H18O4S
• Molecular Weight: 294.372
• Mol file: 104324-44-9.mol

Synonyms:2-(Tetrahydro-furan-2-ylsulfanyl)-benzoic acid tetrahydro-furan-2-yl ester;

Chemical Property of Benzoic acid, 2-[(tetrahydro-2-furanyl)thio]-, tetrahydro-2-furanyl ester

Chemical Property:

• PSA: 70.06000
• LogP: 3.20850

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-[(tetrahydro-2-furanyl)thio]-, tetrahydro-2-furanyl ester

There total 1 articles about Benzoic acid, 2-[(tetrahydro-2-furanyl)thio]-, tetrahydro-2-furanyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chlorotetrahydrofuran (13369-70-5) + Thiosalicylic acid (147-93-3) → 2-tetrahydrofuranyl o-(2-tetrahydrofuranylthio)benzoate (104324-44-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2.5h; Ambient temperature;

DOI:10.1021/ja00282a033

Reference yield: 93.0%

2-tetrahydrofuranyl o-(2-tetrahydrofuranylthio)benzoate (104324-44-9) → o-(2-tetrahydrofuranylthio)benzyl alcohol (104324-45-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 8h; Ambient temperature;

DOI:10.1021/ja00282a033

Reference yield:

2-tetrahydrofuranyl o-(2-tetrahydrofuranylthio)benzoate (104324-44-9) → 2-Propylsulfanylmethyl-benzenethiol (104324-58-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / lithium aluminum hydride / diethyl ether / 8 h / Ambient temperature

2: 91 percent / triethylamine / CH₂Cl₂ / 0.17 h / -10 °C

3: tetrahydrofuran / 0.5 h / Ambient temperature

4: 1.) silver nitrate; 2.) hydrogen sulfide / 1.) water, methanol, heating, 10 min; 2.) methylene chloride, 5 min

With lithium aluminium tetrahydride; hydrogen sulfide; silver nitrate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja00282a033

upstream raw materials:

2-chlorotetrahydrofuran

Thiosalicylic acid

Downstream raw materials:

o-(2-tetrahydrofuranylthio)benzyl alcohol

2-Propylsulfanylmethyl-benzenethiol

allyl (o-mercaptophenyl)methyl sulfide

2-Benzylsulfanylmethyl-benzenethiol