L-N⁴--N¹,N⁸-bis-(2,3-dibenzyloxybenzoyl)spermidine

Base Information

• Chemical Name: L-N⁴--N¹,N⁸-bis-(2,3-dibenzyloxybenzoyl)spermidine
• CAS No.: 161219-92-7
• Molecular Formula: C₅₈H₆₆N₄O₁₀
• Molecular Weight: 979.183
• Mol file: 161219-92-7.mol

Synonyms:

Chemical Property of L-N⁴--N¹,N⁸-bis-(2,3-dibenzyloxybenzoyl)spermidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-N⁴--N¹,N⁸-bis-(2,3-dibenzyloxybenzoyl)spermidine

There total 1 articles about L-N⁴--N¹,N⁸-bis-(2,3-dibenzyloxybenzoyl)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-tert-butoxycarbonyl-L-threonine N-hydroxysuccinimide ester (63076-44-8) + 2,3-bis(benzyloxy)-N-(3-(4-(2,3-bis(benzyloxy)benzamido)butylamino)propyl)benzamide (74272-81-4) → L-N4--N1,N8-bis-(2,3-dibenzyloxybenzoyl)spermidine (161219-92-7)

Guidance literature:

In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85669-6

Reference yield: 56.0%

L-N4--N1,N8-bis-(2,3-dibenzyloxybenzoyl)spermidine (161219-92-7) → L-N4-threonyl-N1,N8-bis-(2,3-dibenzyloxy-benzoyl)spermidine (161219-93-8)

Guidance literature:

With formic acid; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85669-6

Reference yield:

L-N4--N1,N8-bis-(2,3-dibenzyloxybenzoyl)spermidine (161219-92-7) → parabactin (74149-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / formic acid / 3 h / Ambient temperature

2: 90 percent / methanol / 24 h / Heating

3: 88 percent / 10percent palladium(II) hydroxide on charcoal / ethanol; cyclohexene / 3 h / Heating

With formic acid; palladium hydroxide - carbon; In methanol; ethanol; cyclohexene;

DOI:10.1016/S0040-4020(01)85669-6

upstream raw materials:

N-tert-butoxycarbonyl-L-threonine N-hydroxysuccinimide ester

2,3-bis(benzyloxy)-N-(3-(4-(2,3-bis(benzyloxy)benzamido)butylamino)propyl)benzamide

Downstream raw materials:

L-N⁴-threonyl-N¹,N⁸-bis-(2,3-dibenzyloxy-benzoyl)spermidine

parabactin

L-N-<3-(2,3-dibenzyloxybenzamido)propyl>-N-<4-(2,3-dibenzyloxybenzamido)butyl>-2-(2-hydroxyphenyl)-trans-5-methyloxazoline-4-carboxamide