ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

Base Information

Chemical Name:ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate
CAS No.:1531593-86-8
Molecular Formula:C₃₀H₃₀ClFN₆O₃S
Molecular Weight:609.124
Hs Code.:

ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

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Chemical Property of ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

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Technology Process of ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

There total 7 articles about ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1531593-76-6
ethyl 4-[4-({2-[2-(anilinocarbonothioyl)hydrazino]-2-oxoethyl}amino)-2-fluorophenyl] piperazine-1-carboxylate

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1531593-86-8
ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

Guidance literature:: With sodium acetate; In ethanol; for 12h; Reflux;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-73-3
ethyl 4-{4-[(2-ethoxy-2-oxoethyl)amino]-2-fluorophenyl}piperazine-1-carboxylate

: 1531593-86-8
ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 14 h / Reflux

2: ethanol / 10 h / Reflux

3: sodium acetate / ethanol / 12 h / Reflux

With sodium acetate; hydrazine hydrate; In ethanol;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-74-4
ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate

: 1531593-86-8
ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 10 h / Reflux

2: sodium acetate / ethanol / 12 h / Reflux

With sodium acetate; In ethanol;
DOI:10.1007/s00044-013-0898-4