(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

Base Information

Chemical Name:(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone
CAS No.:112332-26-0
Molecular Formula:C₄₀H₅₄N₆O₆
Molecular Weight:714.905
Hs Code.:

(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

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Suppliers and Price of (5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

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Technology Process of (5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

There total 12 articles about (5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.5%

: 119351-81-4
(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 112332-26-0
(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

Guidance literature:: With pyridine; In N,N-dimethyl-formamide;
DOI:10.1039/P29880001743

Reference yield: 17.5%

: 119351-81-4
(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 119351-82-5
C₈₀H₁₀₈N₁₂O₁₂

: 112332-26-0
(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

Guidance literature:: With pyridine; In N,N-dimethyl-formamide;
DOI:10.1039/P29880001743

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 112332-26-0
(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

Guidance literature:: Multi-step reaction with 7 steps

1: DCCI

2: H₂ / Pd-black

3: BtOH, DCCI

4: H₂ / Pd black

5: 574 mg

6: TFA / 0.5 h / 0 °C

7: 17.5 percent / pyridine / dimethylformamide

With pyridine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium; In N,N-dimethyl-formamide;
DOI:10.1039/P29880001743