Technology Process of 2-[3,4-bis((dimethyl-tert-butylsilyl)oxy)phenyl]-2,3-dihydro-8-methoxy-6-methylbenzo[b][1,4]oxathiin-5-ol
There total 10 articles about 2-[3,4-bis((dimethyl-tert-butylsilyl)oxy)phenyl]-2,3-dihydro-8-methoxy-6-methylbenzo[b][1,4]oxathiin-5-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium formate; palladium;
In
ethanol; water; ethyl acetate;
at 90 ℃;
for 4h;
DOI:10.1002/chem.201101146
- Guidance literature:
-
Multi-step reaction with 10 steps
1: potassium hydroxide; hydrazine / ethylene glycol / 19 h / 150 °C / Inert atmosphere
2: triethylamine / dichloromethane / 16 h / 20 °C
3: aluminum (III) chloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4: sodium hydroxide / tetrahydrofuran; water / 16 h / 20 °C
5: sodium hydride / tetrahydrofuran / 0 - 20 °C
6: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
7: sodium hydroxide / methanol / 24 h / 20 °C
8: 2,6-di-tert-butyl-pyridine / chloroform / 0 - 20 °C / Inert atmosphere
9: triethylamine / chloroform / 72 h / 60 °C
10: ammonium formate; palladium / ethanol; water; ethyl acetate / 4 h / 90 °C
With
aluminum (III) chloride; 2,6-di-tert-butyl-pyridine; ammonium formate; sodium hydride; toluene-4-sulfonic acid; palladium; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; ethylene glycol; ethyl acetate;
1: Wolf-Kishner reduction / 6: Baeyer-Villiger oxidation / 9: Diels-Alder reaction;
DOI:10.1002/chem.201101146
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
2: sodium hydroxide / methanol / 24 h / 20 °C
3: 2,6-di-tert-butyl-pyridine / chloroform / 0 - 20 °C / Inert atmosphere
4: triethylamine / chloroform / 72 h / 60 °C
5: ammonium formate; palladium / ethanol; water; ethyl acetate / 4 h / 90 °C
With
2,6-di-tert-butyl-pyridine; ammonium formate; toluene-4-sulfonic acid; palladium; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
methanol; ethanol; dichloromethane; chloroform; water; ethyl acetate;
1: Baeyer-Villiger oxidation / 4: Diels-Alder reaction;
DOI:10.1002/chem.201101146
![2-[3,4-bis((dimethyl-tert-butylsilyl)oxy)phenyl]-5-(benzyloxy)-2,3-dihydro-8-methoxy-6-methylbenzo[b][1,4]oxathiine](/Databaselist/images/loading.webp)
