H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt

Base Information

• Chemical Name: H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt
• CAS No.: 103088-15-9
• Molecular Formula: C₄₅H₅₆N₉O₁₃S₃*Na
• Molecular Weight: 1050.18
• Mol file: 103088-15-9.mol

Synonyms:

Chemical Property of H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt

There total 4 articles about H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-D-tyrosine (70642-86-3) → H-D-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 sodium salt (103088-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / dicyclohexylcarbodiimide / dioxane / 7 - 8 °C

2: 440 mg / Et₃N / dimethylformamide / 72 h / 7 - 8 °C

3: 1.) pyridine-sulfur trioxide, 2.) sodium carbonate / 1.) pyridine, 7 - 8 deg C, 2 d, 2.) H₂O, 30 min

4: 54 mg / trifluoroacetic acid, thioanisole

With methyl-phenyl-thioether; sulfur trioxide pyridine complex; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.959

Reference yield:

Boc-D-Tyr-OSu (102255-97-0) → H-D-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 sodium salt (103088-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 440 mg / Et₃N / dimethylformamide / 72 h / 7 - 8 °C

2: 1.) pyridine-sulfur trioxide, 2.) sodium carbonate / 1.) pyridine, 7 - 8 deg C, 2 d, 2.) H₂O, 30 min

3: 54 mg / trifluoroacetic acid, thioanisole

With methyl-phenyl-thioether; sulfur trioxide pyridine complex; sodium carbonate; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.959

Reference yield:

C50H64N9O15S3(1-)*Na(1+) (67105-75-3,138432-04-9) → H-D-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 sodium salt (103088-15-9)

Guidance literature:

With methyl-phenyl-thioether; trifluoroacetic acid;

DOI:10.1248/cpb.36.959

upstream raw materials:

C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾

N-(tert-butoxycarbonyl)-D-tyrosine

Boc-D-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH₂

Boc-D-Tyr-OSu

Refernces