Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester
• CAS No.: 110403-97-9
• Molecular Formula: C₃₁H₃₉N₃O₁₂S
• Molecular Weight: 677.73

Synonyms:

Chemical Property of Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester

There total 14 articles about Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,6-anhydro-4-O-(2,3-anhydro-4,6-O-benzylidene-α-D-allopyranosyl)-3-O-benzyl-β-D-glucopyranose (114048-01-0) → Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester (110403-97-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 6 h / Ambient temperature

2: sodium azide; ammonium chloride / ethanol / 11 h / 80 - 90 °C

3: sodium tetrahydroborate; sodium acetate; acetic anhydride / 1.) DMSO a) 12 h, RT_. b) 3 h, 0 deg C 2.) dichloromethane-ethanol-water, 0 deg C, 30 min

4: toluene-4-sulfonic acid; acetic acid / 1.) 80-90 deg C, 3 h 2.) acetone, RT, 2 d

5: pyridine / dichloromethane / Ambient temperature

With pyridine; sodium tetrahydroborate; sodium azide; ammonium chloride; sodium acetate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

1,6-anhydro-4',6'-O-benzylidene-2',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-maltose (114129-74-7) → Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester (110403-97-9)

Guidance literature:

Multi-step reaction with 12 steps

1: pyridine / Ambient temperature

2: potassium fluoride; tetraethylammonium chloride / water; acetonitrile / 6 h / Ambient temperature

3: pyridine / 16 h / 0 °C

4: sodium methylate / tetrahydrofuran; methanol / 1 h / Ambient temperature

5: pyridine / dichloromethane / 9 h / 0 °C

6: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / -15 - -10 °C

7: sodium methylate / methanol; dichloromethane / 72 h / 0 °C

8: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 6 h / Ambient temperature

9: sodium azide; ammonium chloride / ethanol / 11 h / 80 - 90 °C

10: sodium tetrahydroborate; sodium acetate; acetic anhydride / 1.) DMSO a) 12 h, RT_. b) 3 h, 0 deg C 2.) dichloromethane-ethanol-water, 0 deg C, 30 min

11: toluene-4-sulfonic acid; acetic acid / 1.) 80-90 deg C, 3 h 2.) acetone, RT, 2 d

12: pyridine / dichloromethane / Ambient temperature

With pyridine; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; sodium azide; ammonium chloride; tetraethylammonium chloride; sodium methylate; sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

1,6-anhydro-4-O-(2,3-anhydro-4,6-O-benzylidene-α-D-allopyranosyl)-3-O-benzyl-2-O-(p-methoxybenzyl)-β-D-glucopyranose (114048-02-1) → Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester (110403-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide; ammonium chloride / ethanol / 11 h / 80 - 90 °C

2: sodium tetrahydroborate; sodium acetate; acetic anhydride / 1.) DMSO a) 12 h, RT_. b) 3 h, 0 deg C 2.) dichloromethane-ethanol-water, 0 deg C, 30 min

3: toluene-4-sulfonic acid; acetic acid / 1.) 80-90 deg C, 3 h 2.) acetone, RT, 2 d

4: pyridine / dichloromethane / Ambient temperature

With pyridine; sodium tetrahydroborate; sodium azide; ammonium chloride; sodium acetate; acetic anhydride; toluene-4-sulfonic acid; acetic acid; In ethanol; dichloromethane;

upstream raw materials:

1,6-anhydro-3-O-benzyl-4-O-(2-azido-2-deoxy-3,4-O-isopropylidene-α-D-allopyranosyl)-2-O-(p-methoxybenzyl)-β-D-glucopyranose

methanesulfonyl chloride

1,6-anhydro-4-O-(2,3-anhydro-4,6-O-benzylidene-α-D-allopyranosyl)-3-O-benzyl-β-D-glucopyranose

1,6-anhydro-4',6'-O-benzylidene-2',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-maltose

Downstream raw materials:

1,6-anhydro-3-O-benzyl-4-O-<2,6-diazido-2,6-dideoxy-3,4-O-isopropylidene-α-D-allopyranosyl>-2-O-(p-methoxybenzyl)-β-D-glucopyranose

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 110403-97-9 Methanesulfonic acid (3aS,4R,6R,7R,7aS)-7-azido-6-[(1R,2R,3S,4R,5R)-3-benzyloxy-4-(4-methoxy-benzyloxy)-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send