Technology Process of methyl 2-((2R)-3-nitro-4-(m-tolylthio)chroman-2-yl)acetate
There total 5 articles about methyl 2-((2R)-3-nitro-4-(m-tolylthio)chroman-2-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0 - 20 °C
2: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
3: benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2 / chloroform / 144 h / -40 - -20 °C
4: dichloromethane / 20 °C
With
benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2; potassium tert-butylate; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; chloroform; tert-butyl alcohol;
3: crossed Rauhut-Currier reaction;
DOI:10.1002/chem.201100479
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
2: benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2 / chloroform / 144 h / -40 - -20 °C
3: dichloromethane / 20 °C
With
benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2; triethylamine; trifluoroacetic anhydride;
In
dichloromethane; chloroform;
2: crossed Rauhut-Currier reaction;
DOI:10.1002/chem.201100479
- Guidance literature:
-
Multi-step reaction with 2 steps
1: benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2 / chloroform / 144 h / -40 - -20 °C
2: dichloromethane / 20 °C
With
benzyl (tert-butoxycarbonyl)oxycarbamate; C32H42N4O2S2;
In
dichloromethane; chloroform;
1: crossed Rauhut-Currier reaction;
DOI:10.1002/chem.201100479
