Technology Process of epinine 4-O-β-glucuronide
There total 7 articles about epinine 4-O-β-glucuronide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water;
at 70 ℃;
for 5h;
Yield given;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / DMF, 1.) 0-5 deg C, 3 h, 2.) 24 h
2: 1.) NaOH / 1.) Bu4NHSO4 / 1.) H2O/CH2Cl2, 10 min, 2.) CH2Cl2/Et2O, overnight
3: 80 percent / NaBH4 / Bu4NHSO4 / H2O; 1,2-dichloro-ethane / 6 h
4: 84 percent / pyridine / 3 h / Ambient temperature
5: H2 / 10 percent Pd/C / acetic acid
6: 20 percent NaOH / H2O / 5 h / 70 °C
With
pyridine; sodium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
water; acetic acid; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / 2 N NaOH / toluene / 2 h / 5 - 10 °C
2: 1.) NaH / DMF, 1.) 0-5 deg C, 3 h, 2.) 24 h
3: 1.) NaOH / 1.) Bu4NHSO4 / 1.) H2O/CH2Cl2, 10 min, 2.) CH2Cl2/Et2O, overnight
4: 80 percent / NaBH4 / Bu4NHSO4 / H2O; 1,2-dichloro-ethane / 6 h
5: 84 percent / pyridine / 3 h / Ambient temperature
6: H2 / 10 percent Pd/C / acetic acid
7: 20 percent NaOH / H2O / 5 h / 70 °C
With
pyridine; sodium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
water; acetic acid; 1,2-dichloro-ethane; toluene;
