Technology Process of Benzenesulfonamide,
4-(4,7-dihydro-1,3-dimethyl-7-oxo-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[
2-(dimethylamino)ethyl]-
There total 7 articles about Benzenesulfonamide,
4-(4,7-dihydro-1,3-dimethyl-7-oxo-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[
2-(dimethylamino)ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2 / 3.5 h / Heating
2: aq. NH4OH / acetone
3: 60 percent / H2 / Raney Ni / methanol; H2O
4: 77 percent / polyphosphoric acid / 6 h / 140 °C
5: SOCl2 / dimethylformamide / 1.5 h
6: dimethylformamide / 1 h / 50 °C
With
ammonium hydroxide; thionyl chloride; PPA; hydrogen;
nickel;
In
methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00384a016
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / conc. H2SO4, 90percent aq. HNO3 / 2.5 h / 80 - 100 °C
2: SOCl2 / 3.5 h / Heating
3: aq. NH4OH / acetone
4: 60 percent / H2 / Raney Ni / methanol; H2O
5: 77 percent / polyphosphoric acid / 6 h / 140 °C
6: SOCl2 / dimethylformamide / 1.5 h
7: dimethylformamide / 1 h / 50 °C
With
ammonium hydroxide; thionyl chloride; PPA; sulfuric acid; hydrogen; nitric acid;
nickel;
In
methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00384a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 60 percent / H2 / Raney Ni / methanol; H2O
2: 77 percent / polyphosphoric acid / 6 h / 140 °C
3: SOCl2 / dimethylformamide / 1.5 h
4: dimethylformamide / 1 h / 50 °C
With
thionyl chloride; PPA; hydrogen;
nickel;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a016
