2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one

Base Information

• Chemical Name: 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one
• CAS No.: 51239-28-2
• Molecular Formula: C₁₇H₁₈N₅O₇PS
• Molecular Weight: 467.399

Synonyms:

Chemical Property of 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one

There total 3 articles about 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H18Cl2N5O6PS → 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one (51239-28-2)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at 0 ℃; Yield given;

DOI:10.1055/s-1989-27150

Reference yield:

8-Benzylthioguanosine (121358-28-9) → 2-Amino-8-benzylsulfanyl-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-purin-6-one (51239-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / various solvent(s) / 1.5 h / 0 °C

2: 0.08 M KOH / acetonitrile; H₂O / 0 °C

With potassium hydroxide; trichlorophosphate; In water; acetonitrile;

DOI:10.1055/s-1989-27150

Reference yield:

→ 8-benzylsulfanyl-O3',O5'-hydroxyphosphoryl-guanosine (51239-28-2)

Guidance literature:

8-Brom-cGMP (2),Thioharnstoff,NaOMe,α-Bromtoluol;

DOI:10.1021/bi00750a014

upstream raw materials:

8-Benzylthioguanosine

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