(2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Base Information

Chemical Name:(2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one
CAS No.:286936-08-1
Molecular Formula:C₁₂H₂₀O₆
Molecular Weight:260.287
Hs Code.:
Mol file:286936-08-1.mol

Synonyms:

Suppliers and Price of (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one
500mg
$ 1320.00

TRC
(2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one
50mg
$ 165.00

Medical Isotopes, Inc.
(2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one
500 mg
$ 2200.00

Total 1 raw suppliers

Chemical Property of (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

Chemical Property:

Melting Point:148-150 °C
Boiling Point:384.3±42.0 °C(Predicted)
PKA:13.09±0.60(Predicted)
Density:1.23±0.1 g/cm3(Predicted)
Solubility.:Chloroform, DCM

Purity/Quality:: (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6(5H)-one is an intermediate in the synthesis of (-)-Altenuene (A575740), a toxin isolated from the fungus Alternaria tenuis.

Technology Process of (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one

There total 5 articles about (2S,3S,4aR,8R,8aR)-Hexahydro-8-hydroxy-2,3-diMethoxy-2,3-diMethyl-1,4-benzodioxin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₁₂H₂₂O₆

: 286936-08-1
(2R,3S,4aR,8R,8aR)-8-hydroxy-2,3-dimethoxy-2,3-dimethylhexahydro-1,4-benzodioxin-6(5H)-one

Guidance literature:: With silica gel-supported NaIO₄; In methanol; dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c1cc11388g

Reference yield: 72.0%

: 286936-07-0
(2S,3S,4aR,5R,7S,8aR)-7-Hydroxymethyl-2,3-dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine-5,7-diol

: 286936-08-1
(2R,3S,4aR,8R,8aR)-8-hydroxy-2,3-dimethoxy-2,3-dimethylhexahydro-1,4-benzodioxin-6(5H)-one

Guidance literature:: With sodium periodate; In phosphate buffer; at 20 ℃; for 1h; pH=7;
DOI:10.1021/ja016460p

Reference yield:

: 176798-26-8
(2S,3S,4aR,6S,8R,8aR)-6,8-Dihydroxy-2,3-dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester

: 286936-08-1
(2R,3S,4aR,8R,8aR)-8-hydroxy-2,3-dimethoxy-2,3-dimethylhexahydro-1,4-benzodioxin-6(5H)-one

Guidance literature:: (2S,3S,4aR,6S,8R,8aR)-6,8-Dihydroxy-2,3-dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester; With sodium tetrahydroborate; In methanol; at 20 ℃; for 18h;

With sodium periodate; In methanol; water; at 20 ℃; for 3h; Further stages.;
DOI:10.1016/j.tetlet.2004.01.148