3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Base Information

Chemical Name:3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester
CAS No.:926653-33-0
Molecular Formula:C₄₀H₅₀F₆O₈SSi
Molecular Weight:832.974
Hs Code.:

3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Synonyms:

Suppliers and Price of 3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

There total 26 articles about 3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 926653-19-2
4-[1-(4-methoxy-benzyloxy)-pent-4-ynyl]-2,2-dimethyl-[1,3]dioxolane

: 926653-33-0
3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 25 steps

1.1: 81 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

2.1: 88 percent / TEA; DMAP / CH₂Cl₂ / 0 °C

3.1: TBAF / tetrahydrofuran

3.2: 91 percent / K₂CO₃ / methanol

4.1: 89 percent / aq. AcOH

5.1: 99 percent / H₂; quinoline / Lindlar catalyst / ethyl acetate

6.1: 97 percent / TEA; DMAP / CH₂Cl₂

7.1: Eu(fod)3 / toluene / 120 °C

7.2: 70 percent / AcOH; H₂O / tetrahydrofuran

8.1: 95 percent / DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 0 °C

9.1: 96 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

10.1: 58 percent / CF₃CO₂H / methanol

11.1: 99 percent / PPTS / CH₂Cl₂

12.1: 98 percent / mCPBA; NaHCO₃ / CH₂Cl₂ / 0 °C

13.1: (PhSe)2; NaBH₄ / ethanol; butan-1-ol / Heating

13.2: H₂O₂; pyridine; 2-methyl-2-butene / CH₂Cl₂

14.1: 85 percent / mCPBA; NaHCO₃ / CH₂Cl₂ / 0 °C

15.1: 92 percent / TEA; DMAP / CH₂Cl₂ / 0 °C

16.1: (PhSe)2; NaBH₄ / ethanol; butan-1-ol / 80 °C

16.2: H₂O₂; pyridine; 2-nethyl-2-butene / CH₂Cl₂

17.1: 75 percent / DIBAL; n-BuLi / toluene / 0 °C

18.1: 100 percent / TBAF / tetrahydrofuran

19.1: 97 percent / imidazole / dimethylformamide

20.1: 97 percent / CBr₄; P(oct)3; TEA / 1-methyl-1-cyclohexene / toluene / 90 °C

21.1: 100 percent / Bu₃SnH; AIBN / toluene / 0 °C / Irradiation

22.1: 78 percent / CSA; (HOCH₂)2 / methanol

23.1: 100 percent / CSA / 1,2-dichloro-ethane

24.1: 97 percent / DIBAL / toluene / -10 °C

25.1: TEA; DMAP / CH₂Cl₂

With 1H-imidazole; 2,6-dimethylpyridine; quinoline; dmap; sodium tetrahydroborate; n-butyllithium; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; TOP; 4 A molecular sieve; TEA; diphenyl diselenide; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; ethylene glycol; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Eu(fod)3; Lindlar's catalyst; 1-methylcyclohex-1-ene; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; butan-1-ol; 1.1: Yamaguchi reaction;
DOI:10.1016/j.tetlet.2006.11.080

Reference yield:

: 926653-41-0
6-(2-benzyloxy-1-hydroxy-ethyl)-2,2-dimethyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol

: 926653-33-0
3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / imidazole / dimethylformamide

2: 97 percent / CBr₄; P(oct)3; TEA / 1-methyl-1-cyclohexene / toluene / 90 °C

3: 100 percent / Bu₃SnH; AIBN / toluene / 0 °C / Irradiation

4: 78 percent / CSA; (HOCH₂)2 / methanol

5: 100 percent / CSA / 1,2-dichloro-ethane

6: 97 percent / DIBAL / toluene / -10 °C

7: TEA; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; TOP; TEA; camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; ethylene glycol; 1-methylcyclohex-1-ene; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2006.11.080

Reference yield:

: 9-[2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-2,3,4,5,8,9-hexahydro-oxonine-2-carbaldehyde

: 926653-33-0
3,5-bis-trifluoromethyl-benzenesulfonic acid 9-(2-benzyloxy-ethyl)-8-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,3,4,7,8,9-hexahydro-oxonin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 15 steps

1.1: 99 percent / PPTS / CH₂Cl₂

2.1: 98 percent / mCPBA; NaHCO₃ / CH₂Cl₂ / 0 °C

3.1: (PhSe)2; NaBH₄ / ethanol; butan-1-ol / Heating

3.2: H₂O₂; pyridine; 2-methyl-2-butene / CH₂Cl₂

4.1: 85 percent / mCPBA; NaHCO₃ / CH₂Cl₂ / 0 °C

5.1: 92 percent / TEA; DMAP / CH₂Cl₂ / 0 °C

6.1: (PhSe)2; NaBH₄ / ethanol; butan-1-ol / 80 °C

6.2: H₂O₂; pyridine; 2-nethyl-2-butene / CH₂Cl₂

7.1: 75 percent / DIBAL; n-BuLi / toluene / 0 °C

8.1: 100 percent / TBAF / tetrahydrofuran

9.1: 97 percent / imidazole / dimethylformamide

10.1: 97 percent / CBr₄; P(oct)3; TEA / 1-methyl-1-cyclohexene / toluene / 90 °C

11.1: 100 percent / Bu₃SnH; AIBN / toluene / 0 °C / Irradiation

12.1: 78 percent / CSA; (HOCH₂)2 / methanol

13.1: 100 percent / CSA / 1,2-dichloro-ethane

14.1: 97 percent / DIBAL / toluene / -10 °C

15.1: TEA; DMAP / CH₂Cl₂

With 1H-imidazole; dmap; sodium tetrahydroborate; n-butyllithium; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; TOP; TEA; diphenyl diselenide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; ethylene glycol; 3-chloro-benzenecarboperoxoic acid; 1-methylcyclohex-1-ene; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; butan-1-ol;
DOI:10.1016/j.tetlet.2006.11.080