N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine

Base Information

• Chemical Name: N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine
• CAS No.: 1027568-41-7
• Molecular Formula: C₂₈H₄₃N₃O₃S
• Molecular Weight: 501.734
• Mol file: 1027568-41-7.mol

Synonyms:

Chemical Property of N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine

There total 6 articles about N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-Methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-propyl-amine (167557-57-5) → N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine (1027568-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / dimethylformamide; CH₂Cl₂

2: (CH₃)2S*BH₃

With dimethylsulfide borane complex; TEA; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction;

DOI:10.1016/S0960-894X(00)00049-4

Reference yield:

(4-methylsulfonylphenyl)acetyl chloride (74426-50-9) → N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine (1027568-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / CH₂Cl₂

2: SOCl₂ / dimethylformamide; CH₂Cl₂

3: TEA / dimethylformamide; CH₂Cl₂

4: (CH₃)2S*BH₃

With sodium hydroxide; thionyl chloride; dimethylsulfide borane complex; TEA; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Chlorination / 3: Condensation / 4: Reduction;

DOI:10.1016/S0960-894X(00)00049-4

Reference yield:

6-[2-(4-methanesulfonyl-phenyl)-acetylamino]-hexanoic acid (178487-20-2) → N'-[2-(4-methanesulfonyl-phenyl)-ethyl]-N-(2-methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-N-propyl-hexane-1,6-diamine (1027568-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / dimethylformamide; CH₂Cl₂

2: TEA / dimethylformamide; CH₂Cl₂

3: (CH₃)2S*BH₃

With thionyl chloride; dimethylsulfide borane complex; TEA; In dichloromethane; N,N-dimethyl-formamide; 1: Chlorination / 2: Condensation / 3: Reduction;

DOI:10.1016/S0960-894X(00)00049-4

upstream raw materials:

(2-Methoxy-5,6,7,8-tetrahydro-quinolin-6-yl)-propyl-amine

(4-methylsulfonylphenyl)acetyl chloride

6-[2-(4-methanesulfonyl-phenyl)-acetylamino]-hexanoic acid

6-aminohexanoic acid