[2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

Base Information

• Chemical Name: [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone
• CAS No.: 929049-23-0
• Molecular Formula: C₃₉H₅₈F₂N₄O₆S₄
• Molecular Weight: 845.174
• Mol file: 929049-23-0.mol

Synonyms:

Chemical Property of [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

There total 6 articles about [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(5-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyloxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone (929049-13-8) → [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone (929049-23-0)

Guidance literature:

With tin(ll) chloride; In methanol; for 2h; Heating;

DOI:10.1016/j.bmcl.2006.10.070

Reference yield:

(2S,4R)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-4-fluoro-pyrrolidine-2-carbaldehyde (929049-03-6) → [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone (929049-23-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / TMSCl / CHCl₃ / 24 h / 20 °C

2: 80 percent / EtSH*BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

3: K₂CO₃ / acetone / Heating

4: SnCl₂*2H₂O / methanol / 2 h / Heating

With chloro-trimethyl-silane; EtSH*BF₃OEt₂; potassium carbonate; tin(ll) chloride; In methanol; dichloromethane; chloroform; acetone;

DOI:10.1016/j.bmcl.2006.10.070

Reference yield:

(2S,4R)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4-fluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal (929049-05-8) → [2-Amino-4-(5-{5-amino-4-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyloxy)-5-methoxy-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone (929049-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / Heating

2: SnCl₂*2H₂O / methanol / 2 h / Heating

With potassium carbonate; tin(ll) chloride; In methanol; acetone;

DOI:10.1016/j.bmcl.2006.10.070

upstream raw materials:

[4-(5-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyloxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

(2S,4R)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-4-fluoro-pyrrolidine-2-carbaldehyde

(2S,4R)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4-fluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

methyl-(2S,4R)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-fluoropyrrolidine-2-carboxylate