benzyl 2-cyanoethyl N,N-diethylphosphoramidite

Base Information

• Chemical Name: benzyl 2-cyanoethyl N,N-diethylphosphoramidite
• CAS No.: 116457-70-6
• Molecular Formula: C₁₄H₂₁N₂O₂P
• Molecular Weight: 280.307
• Mol file: 116457-70-6.mol

Synonyms:

Chemical Property of benzyl 2-cyanoethyl N,N-diethylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-cyanoethyl N,N-diethylphosphoramidite

There total 1 articles about benzyl 2-cyanoethyl N,N-diethylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-β-cyanoethyl-N,N-diisopropylamino-phosphoramidite (110914-51-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2-cyanoethyl N,N-diethylphosphoramidite (116457-70-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/recl.19871061201

Reference yield:

benzyl 2-cyanoethyl N,N-diethylphosphoramidite (116457-70-6) → 3-O-palmitoyl-6-O-benzyloxymethyl-2-deoxy-2-palmitamido-α-D-glucopyranose 1,4-bis(benzylphosphate)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5M 1H-tetrazol / acetonitrile; CH₂Cl₂ / Ambient temperature

2: 80percent tert-butyl hydroperoxide in di-tert-butyl peroxide, triethylamine / dioxane; CH₂Cl₂ / 2 h / Ambient temperature

With 1H-tetrazole; tert-butyl hydroperoxide in di-tert-butyl peroxide; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1002/recl.19871061201

Reference yield:

benzyl 2-cyanoethyl N,N-diethylphosphoramidite (116457-70-6) + 3-O-palmitoyl-6-O-(benzyloxymethyl)-2-deoxy-2-palmitamido-α-D-glucopyranoside (116457-68-2) → Hexadecanoic acid (2R,3R,4R,5S,6R)-2,5-bis-[benzyloxy-(2-cyano-ethoxy)-phosphanyloxy]-6-benzyloxymethoxymethyl-3-hexadecanoylamino-tetrahydro-pyran-4-yl ester

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; Ambient temperature;

DOI:10.1002/recl.19871061201

upstream raw materials:

chloro-β-cyanoethyl-N,N-diisopropylamino-phosphoramidite

benzyl alcohol