(RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

Base Information

Chemical Name:(RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine
CAS No.:64327-51-1
Molecular Formula:C₁₅H₁₆N₂O
Molecular Weight:240.305
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

Chemical Property:

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Technology Process of (RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

There total 21 articles about (RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 86618-46-4,86618-47-5
(RS,RS)-2H-3,4-dihydro-2-phenyl-3-trifluoroacetamidomethyl-1,4-benzoxazine

: 64327-51-1,86618-48-6
(RS,RS)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 2h;

Reference yield:

: 71622-13-4,86618-36-2
ethyl (RS,RS)-2-hydroxy-3-(2-nitrophenoxy)-3-phenylpropanoate

: 64327-51-1,86618-48-6
(RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 0.25 h / 3 - 5 °C

2: 81 percent / NaBH₄, KI, LiCl / tetrahydrofuran / 24 h / Ambient temperature

3: 58 percent / N,N-dimethyl-acetamide / 30 h / 80 °C

4: 85percent N₂H₄*H₂O / dioxane / 0.17 h / Heating

5: 90 percent / triethylamine / CHCl₃ / 0.5 h / -5 °C

6: 78 percent / triethylamine / CH₂Cl₂ / 0.5 h / -5 °C

7: 78 percent / H₂ / 10percent Pd/C / dimethylformamide / 1520 Torr / Ambient temperature

8: 18 percent / sodium acetate / toluene / 216 h / Heating

9: NaBH₄ / ethanol / 2 h

With sodium tetrahydroborate; hydrogen; sodium acetate; hydrazine hydrate; triethylamine; potassium iodide; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 86618-50-0
ethyl (RS,RS)-2-mesyloxy-3-(2-nitrophenoxy)-3-phenylpropanoate

: 64327-51-1,86618-48-6
(RS,SR)-2H-3,4-dihydro-3-aminomethyl-2-phenyl-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / NaBH₄, KI, LiCl / tetrahydrofuran / 24 h / Ambient temperature

2: 58 percent / N,N-dimethyl-acetamide / 30 h / 80 °C

3: 85percent N₂H₄*H₂O / dioxane / 0.17 h / Heating

4: 90 percent / triethylamine / CHCl₃ / 0.5 h / -5 °C

5: 78 percent / triethylamine / CH₂Cl₂ / 0.5 h / -5 °C

6: 78 percent / H₂ / 10percent Pd/C / dimethylformamide / 1520 Torr / Ambient temperature

7: 18 percent / sodium acetate / toluene / 216 h / Heating

8: NaBH₄ / ethanol / 2 h

With sodium tetrahydroborate; hydrogen; sodium acetate; hydrazine hydrate; triethylamine; potassium iodide; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;