C₅₂H₆₃N₅O₉Si₂

Base Information

• Chemical Name: C₅₂H₆₃N₅O₉Si₂
• CAS No.: 398456-08-1
• Molecular Formula: C₅₂H₆₃N₅O₉Si₂
• Molecular Weight: 958.271
• Mol file: 398456-08-1.mol

Synonyms:

Chemical Property of C₅₂H₆₃N₅O₉Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₆₃N₅O₉Si₂

There total 5 articles about C₅₂H₆₃N₅O₉Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C52H61N5O9Si2 (398456-07-0) → C52H63N5O9Si2 (398456-08-1)

Guidance literature:

With Dimethylphenylsilane; trifluoroacetic acid; at 0 ℃; for 3h;

DOI:10.1002/jccs.200100139

Reference yield:

5'-O-(tert-butyldiphenylsilyl)-3'-keto-2'-deoxythymidine (305819-88-9) → C52H63N5O9Si2 (398456-08-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / NaBH₄ / methanol / 0.17 h / 20 °C

2: 88 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 3 h / 0 °C

3: 87 percent / methyl hydrazine / CH₂Cl₂ / 2 h / -10 - 0 °C

4: 85 percent / AcOH / 3 h / 20 °C

5: 55 percent / dimethylphenylsilane; trifluoroacetic acid / 3 h / 0 °C

With sodium tetrahydroborate; Dimethylphenylsilane; acetic acid; triphenylphosphine; methylhydrazine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1002/jccs.200100139

Reference yield:

1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-β-D-erythro-pentofuranosyl]thymine (166955-29-9) → C52H63N5O9Si2 (398456-08-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 3 h / 0 °C

2: 87 percent / methyl hydrazine / CH₂Cl₂ / 2 h / -10 - 0 °C

3: 85 percent / AcOH / 3 h / 20 °C

4: 55 percent / dimethylphenylsilane; trifluoroacetic acid / 3 h / 0 °C

With Dimethylphenylsilane; acetic acid; triphenylphosphine; methylhydrazine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1002/jccs.200100139

upstream raw materials:

C₅₂H₆₁N₅O₉Si₂

5'-O-(tert-butyldiphenylsilyl)-3'-keto-2'-deoxythymidine

1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-β-D-erythro-pentofuranosyl]thymine

3'-O-amino-5'-O-tert-butyldiphenylsilyl-thymidine

Downstream raw materials:

C₅₄H₆₅N₅O₁₀Si₂