Technology Process of 12,13-dimethoxy-8,11,13-podocarpatrien-7-one
There total 1 articles about 12,13-dimethoxy-8,11,13-podocarpatrien-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 82 percent / phosphate acid / toluene / 2 h / 100 °C
2: 91 percent / K2CO3 / acetone / 5 h / 20 °C
3: 85 percent / LiAlH4 / diethyl ether / 4 h / 20 °C
4: 55 percent / pyridine chromium trioxide chloride / CH2Cl2 / 4 h / 20 °C
5: 74.5 percent / n-BuLi / tetrahydrofuran / 6 h / 20 °C
6: 100 percent / H2 / Pd/C / diethyl ether / 0.5 h
7: boron trifluoride etherate / CH2Cl2 / 24 h / 20 °C
8: 85.6 percent / chromium trioxide / CH2Cl2 / 2 h / 20 °C
With
chromium(VI) oxide; lithium aluminium tetrahydride; n-butyllithium; phosphate acid; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2005.11.023
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane / 6 h / -78 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 2 h / 0 °C / Inert atmosphere
3.3: Inert atmosphere
With
potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
1.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1039/c9ob00661c
