(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Base Information

Chemical Name:(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide
CAS No.:103352-48-3
Molecular Formula:C₃₈H₅₅N₇O₆
Molecular Weight:705.898
Hs Code.:

(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Synonyms:

Suppliers and Price of (2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

There total 5 articles about (2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4S,5S)-4-Hydroxy-2-isopropyl-7-methyl-5-{(S)-2-(2-phenoxy-acetylamino)-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

: 103352-48-3
(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: With benzotriazol-1-ol; In methanol; Ambient temperature;
DOI:10.1021/jm00167a009

Reference yield:

: 103372-32-3
N-α-<4(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

: 103352-48-3
(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: HCl (gas) / diethyl ether / 0.25 h

2: diethylphosphoryl cyanide (DEPC), Et₃N / CH₂Cl₂

3: 50 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h

4: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂; dimethylformamide / Ambient temperature

5: 1-hydroxybenzotriazole (1-HOBT) / methanol / Ambient temperature

With hydrogenchloride; diethylphosphoryl cyanide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009

Reference yield:

: 103882-43-5,123537-40-6
(2S,4S,5S)-5-Amino-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide; hydrochloride

: 103352-48-3
(2S,4S,5S)-4-Hydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: diethylphosphoryl cyanide (DEPC), Et₃N / CH₂Cl₂

2: 50 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h

3: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂; dimethylformamide / Ambient temperature

4: 1-hydroxybenzotriazole (1-HOBT) / methanol / Ambient temperature

With diethylphosphoryl cyanide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009