4-chlorocinnamoyl anhydride

Base Information

• Chemical Name: 4-chlorocinnamoyl anhydride
• CAS No.: 1134195-71-3
• Molecular Formula: C₁₈H₁₂Cl₂O₃
• Molecular Weight: 347.197
• Mol file: 1134195-71-3.mol

Synonyms:

Chemical Property of 4-chlorocinnamoyl anhydride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chlorocinnamoyl anhydride

There total 2 articles about 4-chlorocinnamoyl anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 4-chlorocinnamoyl anhydride (1134195-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; piperidine / 80 °C

2: bis(trichloromethyl) carbonate; triethylamine / ethyl acetate / 1 h

With piperidine; pyridine; bis(trichloromethyl) carbonate; triethylamine; In ethyl acetate;

DOI:10.1002/cplu.202000767

Reference yield:

3-(4-chlorophenyl)prop-2-enoic acid (1615-02-7,940-62-5) → 4-chlorocinnamoyl anhydride (1134195-71-3)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In ethyl acetate; for 1h;

DOI:10.1002/cplu.202000767

Reference yield: 24.0%

4-chlorocinnamoyl anhydride (1134195-71-3) + naltrexone methyl ether (16617-07-5) → N-cyclopropylmethyl-14β-4'-chlorocinnamoyloxy-7,8-dihydrocodeinone (1134195-74-6)

Guidance literature:

In toluene; Reflux;

DOI:10.1021/jm8012272

upstream raw materials:

4-chlorobenzaldehyde

3-(4-chlorophenyl)prop-2-enoic acid

Downstream raw materials:

3-O-(tert-butyldimethylsilyl)-14β-(4-chlorocinnamoyloxy)-N-cyclopropylmethyl-7,8-dihydronormorphinone

N-cyclopropylmethyl-14β-4'-chlorocinnamoyloxy-7,8-dihydrocodeinone

dimethyl 3,4-bis(4-chlorophenyl)cyclobutane-1,2-dicarboxylate