1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

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Chemical Name:1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid
CAS No.:139305-75-2
Molecular Formula:2C₄H₄O₄*C₂₉H₂₉FN₂O
Molecular Weight:672.707
Hs Code.:

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Chemical Property of 1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

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Technology Process of 1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

There total 8 articles about 1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: (2E,4E)-1-[4-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-piperazin-1-yl]-5-phenyl-penta-2,4-dien-1-one

: 139305-75-2
1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 2h;
DOI:10.1248/cpb.39.2564

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 139305-75-2
1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1 h / 200 °C

2: 89 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: CH₂Cl₂ / 2 h / Ambient temperature

6: 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

7: 30 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 2 h

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic anhydride; In methanol; dichloromethane; toluene;
DOI:10.1248/cpb.39.2564

Reference yield:

: 371-35-7
sodium 4-fluorophenoxide

: 139305-75-2
1-(2-Fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-yl)-4-((2E,4E)-5-phenyl-penta-2,4-dienyl)-piperazine; compound with (Z)-but-2-enedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1 h / 200 °C

2: 89 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: CH₂Cl₂ / 2 h / Ambient temperature

6: 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

7: 30 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 2 h

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic anhydride; In methanol; dichloromethane; toluene;
DOI:10.1248/cpb.39.2564