(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

Base Information

Chemical Name:(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide
CAS No.:127318-98-3
Molecular Formula:C₂₃H₂₈N₂O₆
Molecular Weight:428.485
Hs Code.:

(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-<N-(1S)-1-phenylethyl>acetamide

Synonyms:

Suppliers and Price of (R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of (R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

Chemical Property:

Purity/Quality:: HPLC≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

There total 1 articles about (R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 102978-41-6
4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione

: 127318-98-3
(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

: 110314-10-8
(S)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

Guidance literature:: at 75 ℃; for 20h;
DOI:10.1021/jm00395a024

Reference yield:

: 127318-98-3
(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

: 127319-02-2
<7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 24 h / Ambient temperature

2: 91 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

3: 290 mg / hydrogen / Raney Ni / acetic acid; ethanol / 11 h / 760 Torr / Ambient temperature; Irradiation

With pyridine; hydrogen; triphenylphosphine; diethylazodicarboxylate; nickel; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1248/cpb.37.3382

Reference yield:

: 127318-98-3
(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

: 127319-01-1
<7-<1-<(1S)-1-phenylethyl>carbamoyl-1-propenyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / 24 h / Ambient temperature

2: 91 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

With pyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1248/cpb.37.3382