allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

Base Information

Chemical Name:allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate
CAS No.:138038-42-3
Molecular Formula:C₄₂H₅₆N₆O₉S₂Si₂
Molecular Weight:909.244
Hs Code.:

allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

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Chemical Property of allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

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Technology Process of allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

There total 1 articles about allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106894-01-3
2-<2-<<(allyloxy)carbonyl>amino>thiazol-4-yl>-2-(Z)-(methoxyimino)acetic acid

: (6R,7S)-7-Amino-3-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-thiazol-4-yl}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester; compound with trifluoro-acetic acid

: 138038-42-3
allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 40 min, 2.) CH₂Cl₂, 0 deg C, 2 h;
DOI:10.7164/antibiotics.47.1052

Reference yield:

: 138038-42-3
allyl 7β-<(2-allyloxycarbonylaminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-<3,4-di<(t-butyldimethylsilyl)oxy>phenyl>thiazol-4-yl>-3-cephem-4-carboxylate

: 7β-<(2-aminothiazol-4-yl)-Z-methoximinoacetylamino>-1-carba(1-dethia)-3-<2-(3,4-dihydroxyphenyl)thiazol-4-yl>-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

2: n-Bu₃SnH / bistriphenylphosphine Pd(II) dichloride / CH₂Cl₂ / 0.33 h

With tri-n-butyl-tin hydride; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane;
DOI:10.7164/antibiotics.47.1052