(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

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Chemical Name:(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate
CAS No.:135697-34-6
Molecular Formula:C₂₉H₃₅N₅O₅
Molecular Weight:533.627
Hs Code.:

(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

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Chemical Property of (S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

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Technology Process of (S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

There total 12 articles about (S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128726-47-6
(+)-(S)-6-hydroxymethyl-2-piperidinone

: 135697-34-6
(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 70.4 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

3: 43 percent / potassium tert-butoxide / dimethylsulfoxide

4: 85 percent / pyridine / 8 h / Ambient temperature

5: 64 percent / 1 M LiOH / 0.67 h / Ambient temperature

6: 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

7: CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; dmap; lithium hydroxide; potassium tert-butylate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00021a010

Reference yield:

: 135697-06-2
(S)-(6-oxo-2-piperidinyl)methyl 4-methylbenzenesulfonate

: 135697-34-6
(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

2: 43 percent / potassium tert-butoxide / dimethylsulfoxide

3: 85 percent / pyridine / 8 h / Ambient temperature

4: 64 percent / 1 M LiOH / 0.67 h / Ambient temperature

5: 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

6: CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; potassium tert-butylate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00021a010

Reference yield:

: 135697-22-2
(S)-1,1-dimethylethyl 2-<(4-methylbenzenesulfonyl)oxy)methyl>-6-oxo-1-piperidinecarboxylate

: 135697-34-6
(S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-5-(benzylamino)pentyl>carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / potassium tert-butoxide / dimethylsulfoxide

2: 85 percent / pyridine / 8 h / Ambient temperature

3: 64 percent / 1 M LiOH / 0.67 h / Ambient temperature

4: 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

5: CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; potassium tert-butylate; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00021a010