tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
CAS No.:161290-62-6
Molecular Formula:C₃₁H₄₂Cl₂N₃O₇P
Molecular Weight:670.57
Hs Code.:

tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

There total 5 articles about tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: C₂HF₃O₂*C₂₁H₂₅Cl₂N₂O₄P

: 161290-62-6
tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 22 ℃; for 12h;
DOI:10.1021/jm300599x

Reference yield:

: 161290-53-5
C₂₄H₂₄Cl₂NO₅P

: 161290-62-6
tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; acetic acid / 2 h / 22 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

3: dichloromethane / 2 h / 22 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

With hydrogen bromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm300599x

Reference yield:

: C₂₆H₃₃Cl₂N₂O₆P

: 161290-62-6
tert-butyl (S)-1-((S)-2-((R,S)-1-(bis(4-chlorophenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 22 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm300599x