Technology Process of (E)-(2R,6S)-1-Benzyloxy-2-benzyloxymethoxy-7-hydroxy-2-((1S,2R,4S)-2-hydroxy-4-vinyl-cyclohexyl)-5,6-dimethyl-hept-4-en-3-one
There total 8 articles about (E)-(2R,6S)-1-Benzyloxy-2-benzyloxymethoxy-7-hydroxy-2-((1S,2R,4S)-2-hydroxy-4-vinyl-cyclohexyl)-5,6-dimethyl-hept-4-en-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 40percent aqueous KOH / ethanol / 2 h / 120 °C
2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / -20 °C
3: Jones reagent / acetone / 0.5 h / 0 °C
4: 1.) cupric acetate monohydrate 2.) lead tetraacetate / pyridine / 1.) 0.5 h, room temperature 2a.) 1 h, 23 deg C 2b.) 2 h, 80 deg C
5: LDA / 1.) -78 deg C, 1 h 2.) -40 deg C, 2 h
6: potassium tert-butoxide/n-butyllithium / hexane / 2 h / 0 °C
With
lead(IV) acetate; potassium hydroxide; n-butyllithium; jones reagent; potassium tert-butylate; copper diacetate; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate;
pyridine;
In
tetrahydrofuran; ethanol; hexane; acetone;
DOI:10.1021/jo00179a018
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) thexylborane 2.) 30percent H2O2, NaOAc / 1.a.) -40 deg C 1.b.) 3 h, 23 deg C 2.) 1 h, 50 deg C
2: 40percent aqueous KOH / ethanol / 2 h / 120 °C
3: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / -20 °C
4: Jones reagent / acetone / 0.5 h / 0 °C
5: 1.) cupric acetate monohydrate 2.) lead tetraacetate / pyridine / 1.) 0.5 h, room temperature 2a.) 1 h, 23 deg C 2b.) 2 h, 80 deg C
6: LDA / 1.) -78 deg C, 1 h 2.) -40 deg C, 2 h
7: potassium tert-butoxide/n-butyllithium / hexane / 2 h / 0 °C
With
lead(IV) acetate; potassium hydroxide; n-butyllithium; jones reagent; thexylborane; potassium tert-butylate; dihydrogen peroxide; copper diacetate; sodium acetate; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate;
pyridine;
In
tetrahydrofuran; ethanol; hexane; acetone;
DOI:10.1021/jo00179a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Jones reagent / acetone / 0.5 h / 0 °C
2: 1.) cupric acetate monohydrate 2.) lead tetraacetate / pyridine / 1.) 0.5 h, room temperature 2a.) 1 h, 23 deg C 2b.) 2 h, 80 deg C
3: LDA / 1.) -78 deg C, 1 h 2.) -40 deg C, 2 h
4: potassium tert-butoxide/n-butyllithium / hexane / 2 h / 0 °C
With
lead(IV) acetate; n-butyllithium; jones reagent; potassium tert-butylate; copper diacetate; lithium diisopropyl amide;
pyridine;
In
hexane; acetone;
DOI:10.1021/jo00179a018
