Technology Process of (3R,6S,8R,11R,13R)-3-benzyl-13-[4-(benzyloxy)but-2-yn-1-yl]-4,6,8,11-tetramethyl-1-oxa-4-azacyclotridec-9-ene-2,5-dione
There total 20 articles about (3R,6S,8R,11R,13R)-3-benzyl-13-[4-(benzyloxy)but-2-yn-1-yl]-4,6,8,11-tetramethyl-1-oxa-4-azacyclotridec-9-ene-2,5-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
at 110 ℃;
for 10h;
Inert atmosphere;
DOI:10.1002/hlca.201200519
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 23 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere
4: toluene / 0.5 h / 20 °C / Inert atmosphere
5: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 10 h / 110 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/hlca.201200519
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water / 3 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
3.2: 5 h / -78 - 0 °C / Inert atmosphere
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 23 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere
7.1: toluene / 0.5 h / 20 °C / Inert atmosphere
8.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 10 h / 110 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hexamethyldisilazane; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; toluene;
3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1002/hlca.201200519
