(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

Base Information

Chemical Name:(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester
CAS No.:117625-44-2
Molecular Formula:C₅₃H₆₅NO₇
Molecular Weight:828.102
Hs Code.:

(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

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Chemical Property of (Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

There total 12 articles about (Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31752-99-5
(-)-Corey lactone 5-(4-phenylbenzoate)

: 117625-44-2
(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: chromium trioxide-dipyridine complex, Celite / CH₂Cl₂ / 0.33 h / 0 °C

2: 1) NaH / 1) 1,2-dimethoxyethane, toluene, 25 deg C, 30 min, 2) 25 deg C, 2 h

3: 47 percent / NaBH₄, CeCl₃*7H₂O / methanol; tetrahydrofuran / 0.17 h / 25 °C

4: K₂CO₃, MeOH

5: PPTS

6: DiBAL

With methanol; sodium tetrahydroborate; cerium(III) chloride; 2,2'-bipyridine-chromium(VI) oxide; Celite; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00121a046

Reference yield:

: 35418-07-6
methyl 3-(4-aminophenyl)propionate

: 117625-44-2
(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / 20 h / 25 °C

2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) toluene, THF, -78 deg C, 30 min

3: 1) NaH / 1) 1,2-dimethoxyethane, toluene, 25 deg C, 30 min, 2) 25 deg C, 2 h

4: 47 percent / NaBH₄, CeCl₃*7H₂O / methanol; tetrahydrofuran / 0.17 h / 25 °C

5: K₂CO₃, MeOH

6: PPTS

7: DiBAL

With pyridine; methanol; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/jm00121a046

Reference yield:

: 2393-17-1
3-(4-aminophenyl)propionic acid

: 117625-44-2
(Z)-7-((1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-{(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-[4-(trityl-amino)-phenyl]-pent-1-enyl}-cyclopentyl)-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: HCl(g) / 20 h / Heating

2: pyridine / 20 h / 25 °C

3: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) toluene, THF, -78 deg C, 30 min

4: 1) NaH / 1) 1,2-dimethoxyethane, toluene, 25 deg C, 30 min, 2) 25 deg C, 2 h

5: 47 percent / NaBH₄, CeCl₃*7H₂O / methanol; tetrahydrofuran / 0.17 h / 25 °C

6: K₂CO₃, MeOH

7: PPTS

8: DiBAL

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/jm00121a046