methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

Base Information

Chemical Name:methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate
CAS No.:1383816-30-5
Molecular Formula:C₃₀H₂₇F₄N₃O₄S
Molecular Weight:601.622
Hs Code.:

methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

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Chemical Property of methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

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Technology Process of methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

There total 10 articles about methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924287-65-0
methyl 2-bromo-4-fluoro-1,3-benzothiazole-6-carboxylate

: 1383822-34-1
4-((8-azabicyclo[3.2.1]octan-3-yloxy)methyl)-5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazole

: 1383816-30-5
methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl acetamide; at 60 ℃; for 1h;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: 74467-00-8
N-[[2-(trifluoromethyl)phenyl]methylidene]hydroxylamine

: 1383816-30-5
methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

2.1: potassium carbonate / tetrahydrofuran / 0.08 h / -10 °C

2.2: -5 - 35 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C / Inert atmosphere

4.1: triphenylphosphine / dichloromethane

4.2: 1 h

5.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

5.2: Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: [5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methanol

: 1383816-30-5
methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / dichloromethane

1.2: 1 h

2.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

2.2: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

With 18-crown-6 ether; potassium tert-butylate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/acs.jmedchem.7b00907