Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

Base Information

Chemical Name:Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester
CAS No.:130954-70-0
Molecular Formula:C₃₉H₄₂ClN₆O₈P
Molecular Weight:789.225
Hs Code.:

Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

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Chemical Property of Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

There total 1 articles about Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130954-62-0
methyl 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-(2-cyanoethyl)deoxyguanosin-3'-yl phosphonate

: 130954-70-0
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: With pyridine; perdeuteriopyridine; tris(2,4,6-tribromo-phenoxy)dichlorophosphorane; for 0.0833333h;
DOI:10.1021/jo00003a056

Reference yield:

: 130954-70-0
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

: 130954-83-5
C₃₉H₄₂N₆O₁₀P^(1-)

Guidance literature:: With water; iodine; In pyridine; perdeuteriopyridine; for 0.166667h;
DOI:10.1021/jo00003a056

Reference yield:

: 130954-70-0
Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2-cyano-ethoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester methyl ester

: 130954-76-6
C₆₃H₆₃N₈O₁₆P

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine, pyridine-d5 / 0.08 h

2: I₂-H₂O / pyridine; pyridine-d5 / 0.17 h

With pyridine; perdeuteriopyridine; water; iodine; In pyridine; perdeuteriopyridine;
DOI:10.1021/jo00003a056