Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester

Base Information

• Chemical Name: Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester
• CAS No.: 109545-45-1
• Molecular Formula: C₄₆H₅₀N₄O₁₀P₂
• Molecular Weight: 880.871
• Mol file: 109545-45-1.mol

Synonyms:

Chemical Property of Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester

There total 1 articles about Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-1,2,3,4-Tetra-O-benzyl-myo-inositol (6195-66-0,13035-64-8,24558-76-7,24558-77-8,26276-99-3,28140-40-1,97465-26-4,109584-31-8,110550-24-8,110550-26-0,115116-22-8,131233-74-4,141040-35-9,141040-41-7,142436-07-5) + bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) → Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester (109545-45-1)

Guidance literature:

DOI:10.1016/S0008-6215(00)90497-X

Reference yield:

Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester (109545-45-1) → (+/-)-1,2,3,4-Tetra-O-benzyl-myo-inositol 5,6-bis(disodium phosphate) (141116-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: m-chloroperoxybenzoic acid

2: 85 percent / 1M NaOH / methanol / 1 h / 50 °C

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In methanol;

DOI:10.1016/S0008-6215(00)90497-X

Reference yield:

Phosphorous acid bis-(2-cyano-ethyl) ester (1R,2S,3S,4R,5S,6R)-2,3,4,5-tetrakis-benzyloxy-6-[bis-(2-cyano-ethoxy)-phosphanyloxy]-cyclohexyl ester (109545-45-1) → (+/-)-1,2,3,4-Tetra-O-benzyl-myo-inositol 5,6-bis (109545-46-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; Yield given;

DOI:10.1016/S0008-6215(00)90497-X

upstream raw materials:

rac-1,2,3,4-Tetra-O-benzyl-myo-inositol

bis(2-cyanoethyl) diisopropylamidophosphite

Downstream raw materials:

(+/-)-1,2,3,4-Tetra-O-benzyl-myo-inositol 5,6-bis

(+/-)-1,2,3,4-Tetra-O-benzyl-myo-inositol 5,6-bis(disodium phosphate)