Technology Process of (4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-phenyloxazole
There total 4 articles about (4R)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-phenyloxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
toluene;
at 120 ℃;
for 68h;
optical yield given as %de;
Inert atmosphere;
DOI:10.1055/s-0030-1260124
- Guidance literature:
-
Multi-step reaction with 2 steps
1: zinc(II) chloride / chlorobenzene / 130 °C
2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 68 h / 120 °C / Inert atmosphere
With
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate;
In
chlorobenzene; toluene;
2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124
- Guidance literature:
-
Multi-step reaction with 2 steps
1: zinc(II) chloride / chlorobenzene / 130 °C
2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 68 h / 120 °C / Inert atmosphere
With
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate;
In
chlorobenzene; toluene;
2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124
