({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester
CAS No.:631910-70-8
Molecular Formula:C₂₅H₂₃BrFN₅O₆S₃
Molecular Weight:684.588
Hs Code.:

({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

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Chemical Property of ({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

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Technology Process of ({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

There total 13 articles about ({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288370-80-9
4-amino-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

: 631910-70-8
({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. HCl; t-butyl nitrite

1.2: 35 percent / CuCl₂*H₂O; SO₂ / H₂O

2.1: 87 percent / sodium sulfite; NaHCO₃

3.1: 60 percent / aq. AcOH / ethanol

4.1: aq. sodium dithionite / ethanol

5.1: Heating

6.1: trimethylaluminium; ammonium chloride / toluene / 90 °C

With hydrogenchloride; tert.-butylnitrite; sodium dithionite; ammonium chloride; trimethylaluminum; sodium hydrogencarbonate; acetic acid; sodium sulfite; In ethanol; toluene;
DOI:10.1016/j.bmcl.2006.01.036

Reference yield:

: 631909-59-6
4-Chlorosulfonyl-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

: 631910-70-8
({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / sodium sulfite; NaHCO₃

2: 60 percent / aq. AcOH / ethanol

3: aq. sodium dithionite / ethanol

4: Heating

5: trimethylaluminium; ammonium chloride / toluene / 90 °C

With sodium dithionite; ammonium chloride; trimethylaluminum; sodium hydrogencarbonate; acetic acid; sodium sulfite; In ethanol; toluene;
DOI:10.1016/j.bmcl.2006.01.036

Reference yield:

: 631912-14-6
4-amino-3-bromo-5-nitro-benzenesulfonyl chloride

: 631910-70-8
({4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophen-2-yl}-imino-methyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: sodium sulfite

2: dimethylformamide / 0 - 20 °C

3: tetrahydrofuran; ethanol / -78 °C

4: Fe; aq. ammonium chloride

5: Heating

6: trimethylaluminium; ammonium chloride / toluene / 90 °C

With ammonium chloride; trimethylaluminum; iron; sodium sulfite; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2006.01.036