Technology Process of (1S,2R)-1-(dimethylphenylsilyl)-2-phenylcyclohexane
There total 6 articles about (1S,2R)-1-(dimethylphenylsilyl)-2-phenylcyclohexane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride; zinc(II) chloride;
In
methanol; ethanol;
at 60 ℃;
DOI:10.1016/j.tet.2007.05.086
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Li; CuCN / tetrahydrofuran / -30 - 0 °C
1.2: 71 percent / tetrahydrofuran / 5.5 h / -23 - 20 °C
2.1: Chiral AD column / hexane; propan-2-ol
3.1: ethanol / 60 °C
4.1: NaBH3(CN); ZnCl2 / ethanol; methanol / 60 °C
With
chiral AD column; lithium; sodium cyanoborohydride; zinc(II) chloride;
In
tetrahydrofuran; methanol; ethanol; hexane; isopropyl alcohol;
1.2: Michael addition;
DOI:10.1016/j.tet.2007.05.086
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: tetrahydrofuran; hexane / 2 h / -23 °C
1.3: 65 percent / p-toluenesulfonic acid / toluene / 2 h / Heating
2.1: Li; CuCN / tetrahydrofuran / -30 - 0 °C
2.2: 71 percent / tetrahydrofuran / 5.5 h / -23 - 20 °C
3.1: Chiral AD column / hexane; propan-2-ol
4.1: ethanol / 60 °C
5.1: NaBH3(CN); ZnCl2 / ethanol; methanol / 60 °C
With
chiral AD column; lithium; sodium cyanoborohydride; zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ethanol; hexane; isopropyl alcohol;
2.2: Michael addition;
DOI:10.1016/j.tet.2007.05.086
