Technology Process of (-)-(1R)-(1α,2β,3β,4α,6α)-6-ammonio-4-O-methyl-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate
There total 6 articles about (-)-(1R)-(1α,2β,3β,4α,6α)-6-ammonio-4-O-methyl-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate which
guide to synthetic route it.
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synthetic route:
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87902-30-5,121916-52-7
DL-(1α,2α,3β,4β,5α)-1,2-anhydro-3-O,4-N-carbonyl-5-O-methyl-4-(methylamino)-1,2,3,5-cyclohexanetetrol
- Guidance literature:
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Multi-step reaction with 6 steps
1: 97 percent / KI / acetic acid / 2.5 h / Ambient temperature
2: 2,6-bis(diethylamino)pyridine
3: tetrametyhlguanidinium azide, molecular sieves (3 Angstroem) / acetonitrile / 24 h / 50 °C
4: NaOH / methanol
5: H2 / Pd/C / methanol / 12 h / Ambient temperature
6: 1) Ba(OH)2*8H2O, 2) conc. H2SO4 / 1) CH3OH/H2O, reflux, 4 h, 2) CH3OH/H2O
With
N2,N2,N6,N6-tetraethylpyridine-2,6-diamine; barium dihydroxide; sodium hydroxide; 3 A molecular sieve; tetrametyhlguanidinium azide; sulfuric acid; hydrogen; potassium iodide;
palladium on activated charcoal;
In
methanol; acetic acid; acetonitrile;
- Guidance literature:
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Multi-step reaction with 5 steps
1: 2,6-bis(diethylamino)pyridine
2: tetrametyhlguanidinium azide, molecular sieves (3 Angstroem) / acetonitrile / 24 h / 50 °C
3: NaOH / methanol
4: H2 / Pd/C / methanol / 12 h / Ambient temperature
5: 1) Ba(OH)2*8H2O, 2) conc. H2SO4 / 1) CH3OH/H2O, reflux, 4 h, 2) CH3OH/H2O
With
N2,N2,N6,N6-tetraethylpyridine-2,6-diamine; barium dihydroxide; sodium hydroxide; 3 A molecular sieve; tetrametyhlguanidinium azide; sulfuric acid; hydrogen;
palladium on activated charcoal;
In
methanol; acetonitrile;
- Guidance literature:
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Multi-step reaction with 7 steps
1: 20 percent / 2-(tert-butylimino)-2-(diethylamino)hexahydro-1,3-dimethyl-1,3,2λ5-diazaphosphorine / acetonitrile / 48 h / Ambient temperature
2: 97 percent / KI / acetic acid / 2.5 h / Ambient temperature
3: 2,6-bis(diethylamino)pyridine
4: tetrametyhlguanidinium azide, molecular sieves (3 Angstroem) / acetonitrile / 24 h / 50 °C
5: NaOH / methanol
6: H2 / Pd/C / methanol / 12 h / Ambient temperature
7: 1) Ba(OH)2*8H2O, 2) conc. H2SO4 / 1) CH3OH/H2O, reflux, 4 h, 2) CH3OH/H2O
With
N2,N2,N6,N6-tetraethylpyridine-2,6-diamine; barium dihydroxide; sodium hydroxide; 3 A molecular sieve; tetrametyhlguanidinium azide; sulfuric acid; hydrogen; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; potassium iodide;
palladium on activated charcoal;
In
methanol; acetic acid; acetonitrile;
