(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

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Chemical Name:(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester
CAS No.:121125-16-4
Molecular Formula:C₄₈H₄₆F₅N₃O₁₀
Molecular Weight:919.899
Hs Code.:

(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

There total 13 articles about (S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 121125-16-4
(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

2: H₂ / (+) / methanol / 72 h / 20 °C

4: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

5: Irradiation

6: H₂ / (+) / methanol / 72 h / 20 °C

7: 1) Me₃SiOSO₂CF₃, 2) EDCl / 1) CH₂Cl₂, -40 to 20 deg C, 2 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

8: 1) Bu₄NF, 2) EDCl / 1) DMF, 1 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (+); In methanol; dichloromethane;

Reference yield:

: 118553-54-1
Benzyl 2-tert-butoxycarbonylamino-2-(dimethoxyphosphoryl)acetate

: 121125-16-4
(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

2: H₂ / (+) / methanol / 72 h / 20 °C

4: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

5: Irradiation

6: H₂ / (+) / methanol / 72 h / 20 °C

7: 1) Me₃SiOSO₂CF₃, 2) EDCl / 1) CH₂Cl₂, -40 to 20 deg C, 2 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

8: 1) Bu₄NF, 2) EDCl / 1) DMF, 1 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (+); In methanol; dichloromethane;

Reference yield:

: 130247-03-9
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-3-bromobenzene

: 121125-16-4
(S)-2-Benzyloxycarbonylamino-3-{3'-[(S)-2-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-ethyl]-4-methoxy-biphenyl-3-yl}-propionic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / (+) / methanol / 72 h / 20 °C

3: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

4: Irradiation

5: H₂ / (+) / methanol / 72 h / 20 °C

6: 1) Me₃SiOSO₂CF₃, 2) EDCl / 1) CH₂Cl₂, -40 to 20 deg C, 2 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

7: 1) Bu₄NF, 2) EDCl / 1) DMF, 1 h, 2) CH₂Cl₂, -15 to 20 deg C, 14 h

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (+); In methanol; dichloromethane;